Mahidol University Annual Research Abstracts 2000 109 SEIZURES AFTER INTRACRANIAL SURGERY IN PEDIATRIC PATIENTS Anannit Visudthibhan, Pongsakdi

Seizures After Intracranial Surgery In Pediatric Patients

Mahidol University Annual Research Abstracts 2000 109 SEIZURES AFTER INTRACRANIAL SURGERY IN PEDIATRIC PATIENTS Anannit Visudthibhan, Pongsakdi Visudhiphan, Surang Chiemchanya, Chintana Srirattanajaree Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand. We retrospectively reviewed the occurrence of seizure after performing intracranial operations in children aged less than 15 years. During a 5-year period, there were 18 patients out of a total of 155 who developed one or more seizures within 1 year after operation. The majority of patients (55.6%) had the onset of seizures within 24 hours. Seventy-two percent of the patients had partial seizures. Two patients who developed immediate postoperative seizures had sodium derangement. Eight of 10 patients who had early onset seizures had had an operation for supratentorial lesions. Among the 6 patients who developed seizures after infratentorial tumor removal, the cause of seizure was not known in 4 patients. We emphasize that prompt investigations to exclude any structural lesions and other possible causes of seizure, especially electrolyte disturbance along with appropriate antiepileptic drug administration, are important in patients who develop seizures after the operation. The recommendation for routine administration of antiepileptic drug prior to the operation has yet to be concluded. (J Med Assoc Thai 1999; 82(Suppl 1):S111) PLASMA FREE AMINO ACID CONTENTS IN HEALTHY THAI SUBJECTS Prapaisri Sirichakwal1, Belen Feungpean2, Kraisid Tontisirin3 1Institute of Nutrition, 2Research Center, 3Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Thailand. This preliminary investigation determined the plasma amino acid concentrations in 136 healthy subjects. The subjects were divided into four groups according to their ages: gr 1; 1-3 years, gr 2; 4-11 years, gr 3; 12-19 years and gr 4; 20-45 years. Comparing among the groups, the results showed that in younger children (age 1-3 years) the essential amino acids were slightly lower than the other groups. A wide range for most amino acids were observed. The ratio of essential (EAA): non-essential amino acid (NEAA) in very young children (1-3 years) was lower than children, adolescents and adults. These ratios were normal (> 0.5). The data have been compared with those from several studies performed in normal healthy subjects of different age groups, races and dietary habits. The results showed that most of the mean values of individual amino acid were higher than others except cystine. The EAA:NEAA ratio of each age group was comparable with other reports. The mean values of plasma amino acids and EAA:NEAA ratio in healthy subjects were determined for diagnosis, follow up and prognosis of malnourished condition, abnormal amino acid metabolism and as a reference for other purposes. (J Med Assoc Thai 1999; 82(Suppl 1):S129)



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